Front Cover: ( p‐ (Diphenylarsino)phenyl)diphenylphosphine as a Novel Template for Heterodinuclear Complexes (2/2021)

Nuclease activity of heterodinuclear platinum/copper complexes, a novel approach in drug design

cis-Diamminedichloroplatinum(II), generally referred to as cisplatin (see figure), is widely used as a chemotherapeutic agent to cure solid tumor cancers, such as testicular and ovarian cancer [1]. The clinical use of cisplatin is beyond any doubt very successful, but the treatment is accompanied by serious side effects and acquired tumor resistance. In order to decrease or to overcome these pr...

P 107: P2x7 Receptors: as a Novel Targets for the Treatment of Neuroinflammation

P2x7 receptors are Purineric receptors that are extracellular ATP-gated ion channel. These receptors require high dose or prolonged exposure to ATP for initial activation. The Activation of these receptors facilitates the formation of inflammasome which activates caspase 1. The P20 and P10 subunits of caspase 1 form active enzyme that then releases active interleukin (IL)-1 β and IL-18, tu...

Proceedings Front Cover 8X10

The integrated Rule Oriented Data Management System (iRODS) is a policy-driven data management system that is starting to be used by projects with large data volume requirements that require a highly available system. In this paper we describe an approach to provide a Highly Availability load-balanced iRODS System (HAIRS). We also describe the advantages and disadvantages of the approach and fu...

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